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WT-161

Supplier:
Catalogue number:
B2219-25
Size:
25 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£632.00 Estimated delivery Wed 28 Apr
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WT-161 is a potent, selective, and bioavailable HDAC6 (histone deacetylase-6) inhibitor (IC₅₀ 0.40 nM). It is selective for HDAC6 over HDAC3 (IC₅₀ = 51.61 nM) and induces α-tubulin acetylation, an HDAC6-dependent process, with minimal effect on global lysine acetylation. WT161 inhibits growth of patient-derived multiple myeloma cell lines with IC₅₀ values ranging from 1.5 to 4.7 µM. WT161 enhances the cytotoxicity of bortezomib (Cat. No. 1846) and carfilzomib (Cat. No. 2385) against patient-derived multiple myeloma cells.

Product Type:

Biochemicals

CAS Number:

1206731-57-8

Storage Temp:

-20°C

Compound Purity:

≥98% by HPLC

Molecular Weight:

458.56

UNSPSC Code:

12352200

WT-161

WT-161