£691.00
Estimated delivery Tue 30 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
125079-83-6
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
252.3
Alternative Names:
7-(3-methylphenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
An antagonist of TLR8 (Kd = 220 nM; IC50 = 67 nM in a reporter assay); is selective for TLR8 over a panel of all other human TLRs at 1 µM; inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells at 1 µM; inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human PBMCs in a concentration-dependent manner; decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.
Storage Temperature:
-20°C
