CU-CPT8m
Supplier:
Catalogue number:
CAY25349-25 mg
Size:
25 mg
Product is available in:
£546.00
Estimated delivery Tue 4 May
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An antagonist of TLR8 (Kd = 220 nM; IC50 = 67 nM in a reporter assay); is selective for TLR8 over a panel of all other human TLRs at 1 µM; inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells at 1 µM; inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human PBMCs in a concentration-dependent manner; decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.
Product Type:
Biochemicals
CAS Number:
125079-83-6
Alternative Names:
7-(3-methylphenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxamide
Storage Temp:
-20°C
Formulation:
A crystalline solid
Compound Purity:
≥98%
UNSPSC Code:
12352200
