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Glycine-β-muricholic Acid

Catalogue number:
CAY9003230-5 mg
Supplier:
Size:
5 mg _$$_
Product is available in:
  • UK
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£524.00 Estimated delivery Tue 9 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

66225-78-3

Purity:

≥95%

Formulation:

A crystalline solid

Molecular Weight:

465.6

Alternative Names:

n-[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]-glycine, gly-mca, gβmca

Product Description:

An intestine-selective FXR antagonist; glycine-conjugated form of β-muricholic acid; inhibits chenodeoxycholic acid- and GW 4064-induced expression of the FXR target genes Shp and Fgf15 at 100 µM; resistant to hydrolysis by fecal BSH isolated from gut microbiota; decreases Shp and Fgf15 mRNA expression in ileum, but not liver, and reduces ceramide levels and expression of various ceramide synthesis-related genes in ileum of mice with high-fat diet-induced obesity and db/db mice at 10 mg/kg; prevents weight gain, reduces blood glucose levels, and increases insulin sensitivity as well as prevents development of cholestasis and necrotic lesions in liver of mice with high-fat diet-induced obesity

Storage Temperature:

-20°C

CAY9003230-5 mg: Glycine-β-muricholic Ac
CAY9003230-5 mg: Glycine-β-muricholic Acid
Details Cat number & supplier Size Price
Glycocholic Acid CAY20276-5 g · Cayman Chemical
CAY20276-5 g
Cayman Chemical
5 g £198.00
5 g
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