AAT-008
Catalogue number:
CAY21810-1 mg
Supplier:
Size:
1 mg
Product is available in:
£41.00
Estimated delivery Wed 17 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
847727-81-5
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C21H16ClFN2O4
Molecular Weight:
414.8
Alternative Names:
4-[(1s)-1-[[[5-
Product Description:
An orally bioavailable, potent, and selective EP4 receptor antagonist (IC50 = 16.3 nM in a human EP4 functional assay); selective for EP4, with IC50 values of 2.4, 1,890, >20,000, and >20,000 nM for binding to human EP4, EP2, EP1, and EP3, respectively; has potent binding affinity for human, rat, and dog EP4 (Kis = 0.97, 6.1, and 38 nM, respectively; suppresses PGE2-induced elevation of intracellular cAMP in vitro (pA2 = 1.1 nM); reduces carrageenan-induced mechanical hyperalgesia in rats in a dose-dependent manner
