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Mouse Anti-Human CD107b-AF700

Supplier:
Catalogue number:
9840-27
Size:
100 tests
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£259.00 Estimated delivery Fri 15 Jul
Shipping is calculated in checkout

CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed in lysosomal/endosomal membranes and on the surface of activated platelets and some tumor cell lines including U937 and KG1a. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.

Product Type:

Antibodies

Alternative Names:

LAMP-2, lysosome-associated membrane protein 2

Species Reactivity:

Human, Rhesus, African Green Monkey

Immunogen:

Human adherent peripheral blood cells

Storage Temp:

2 - 8°C

Antibody Host:

Mouse

Antibody Isotype:

IgG1

Antibody Type:

Monoclonal

Clone Number:

H4B4

UNSPSC Code:

12352203

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