£977.00
Estimated delivery Tue 30 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1308631-40-4
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
265.7
Alternative Names:
n-(4-chloro-2-fluorophenyl)-2-hydroxy-benzamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A derivative of salicylanilide with anti-inflammatory activities; inhibits RANKL-induced osteoclast differentiation of BMDMs and RAW 264.7 cells at 10 and 15 µM; decreases RANKL-induced expression of the osteoclastogenic genes Nfatc1, Acp5, Ctsk, Oscar, Itgb3, and Dcstamp in BMDMs and inhibits phosphorylation of IĸB and nuclear translocation of NF-ĸB in RANKL-stimulated RAW 264.7 cells at 15 µM; reduces collagen-induced increases in the serum levels of TNF-α and IL-1β, as well as the numbers of osteoclasts and histological severity of bone erosion, cartilage damage, and synovial inflammation in joints in a mouse model of arthritis at 62.5 mg/kg
Storage Temperature:
-20°C
