£392.00
Estimated delivery Tue 9 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
444930-42-1
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
310.4
Alternative Names:
3-methyl-2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide-2-thiophenecarboxylic acid
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of PCNA; binds to PCNA trimers (Kd = 0.41 µM) and reduces the level of chromatin-associated PCNA in PC3 cells; preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 µM) over non-transformed cells (IC50s = 0.99-2 µM); reduces tumor growth in an LNCaP prostate cancer mouse xenograft model at 10 mg/kg administered five days per week for two weeks
Storage Temperature:
-20°C