Benserazide (hydrochloride)
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14919-77-8
≥95%
A crystalline solid
293.7
2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide-serine, monohydrochloride, ro 4-4602
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- MSDS: View or download
An AADC inhibitor (IC50 = 0.53 µM); inhibits tryptophan oxygenase and kynureninase (Kis = 41.8 and 26.4 µM, respectively, in rat liver homogenates), as well as HK2, HK1, and HK4 (IC50s = 5.5, 25.1, and 40.5 µM, respectively, for the recombinant human enzymes); is cytotoxic to SW480 cells, an effect that can be reversed by HK2 siRNA knockdown, at 50-400 µM; inhibits proliferation of SW480, LoVo, HCT116, MCF-7, and SMMC-7721 cells (IC50s = 143, 151, 181.4, 186, and 210.4 nM, respectively); reduces tumor growth in an SW480 mouse xenograft model at 300 and 600 mg/kg per day for 16 days; inhibits striatal AADC and enhances L-DOPA-induced increases in striatal dopamine levels in a mouse model of 6-OHDA-induced Parkinson's disease at 10 and 50 mg/kg
-20°C