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Benserazide (hydrochloride)

Catalogue number:
CAY20298-5 g
Supplier:
Size:
5 g _$$_
Product is available in:
  • UK
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£315.00 Estimated delivery Tue 9 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

14919-77-8

Purity:

≥95%

Formulation:

A crystalline solid

Molecular Weight:

293.7

Alternative Names:

2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide-serine, monohydrochloride, ro 4-4602

Product Description:

An AADC inhibitor (IC50 = 0.53 µM); inhibits tryptophan oxygenase and kynureninase (Kis = 41.8 and 26.4 µM, respectively, in rat liver homogenates), as well as HK2, HK1, and HK4 (IC50s = 5.5, 25.1, and 40.5 µM, respectively, for the recombinant human enzymes); is cytotoxic to SW480 cells, an effect that can be reversed by HK2 siRNA knockdown, at 50-400 µM; inhibits proliferation of SW480, LoVo, HCT116, MCF-7, and SMMC-7721 cells (IC50s = 143, 151, 181.4, 186, and 210.4 nM, respectively); reduces tumor growth in an SW480 mouse xenograft model at 300 and 600 mg/kg per day for 16 days; inhibits striatal AADC and enhances L-DOPA-induced increases in striatal dopamine levels in a mouse model of 6-OHDA-induced Parkinson's disease at 10 and 50 mg/kg

Storage Temperature:

-20°C

CAY20298-5 g: Benserazide (hydrochloride
CAY20298-5 g: Benserazide (hydrochloride)
Details Cat number & supplier Size Price
Benserazide-d3 (hydrochloride) CAY29643-2.5 mg · Cayman Chemical
CAY29643-2.5 mg
Cayman Chemical
2.5 mg £419.00
2.5 mg
view