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β-Glycyrrhetinic acid

Catalogue number:
Supplier:
BioVision
Size:
1 g _$$_
Product is available in:
  • UK
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CAS Number:

471-53-4

Purity:

≥97% by titration

Molecular Weight:

470

Alternative Names:

3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic acid, Enoxolone; STX352; GM1658; NSC 35347

Product Description:

β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin, one of the main constituents of licorice. It inhibits 15-PGDH (15-hydroxyprostaglandin dehydrogenase) leading to increased prostaglandin concentration in the digestive system. Displays anti-ulcerative, anti-inflammatory, and immunomodulatory properties. In addition, β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC₅₀ values of 16.1, 19.3, 15.8, and 13.7 µM, respectively. Also protects liver against the toxic effect of chemotherapeutic alkylating agents via activation of Nrf2 (NF-E2-related factor-2) and PPARγ.

Storage Temperature:

-20°C

β-Glycyrrhetinic acid
β-Glycyrrhetinic acid