P505-15 hydrochloride
Catalogue number:
9583-5
Supplier:
BioVision
Size:
5 mg _$$_
Product is available in:
N/A
Shipping is calculated in checkout
This product is no longer available to order.
CAS Number:
1370261-97-4
Purity:
≥98% by HPLC
Molecular Weight:
429
Alternative Names:
2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride; PRT062607; PRT2607; BIIB-057
- Data sheet: View or download
- MSDS: View or download
Product Description:
P505-15 is a potent, cell-permeable, highly selective, small molecule SYK inhibitor (IC₅₀ = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. P505-15 blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.28 µM, respectively), as well as Fcɛ receptor 1-mediated basophil degranulation (IC₅₀ = 0.15 µM).
Storage Temperature:
-20°C