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Purity:
≥98% by HPLC
Molecular Weight:
489
Alternative Names:
2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor. It inhibits ULK1 kinase with IC₅₀ of 108 nM and the highly related kinase ULK2 with IC₅₀ of 711 nM. SBI-0206965 suppresses ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergizes with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells.
Storage Temperature:
-20°C
