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CAS Number:
894187-61-2
Purity:
≥98% by HPLC
Molecular Weight:
461
Alternative Names:
4-(5-methyl-4-(tosylmethyl)oxazol-2-yl)-N-(pyridin-3-ylmethyl)benzamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
STF-118804 is a potent and highly specific inhibitor of Nampt (nicotinamide phosphoribosyl transferase) (IC₅₀s = 3-6 nM) that prevents NAD⁺ synthesis from nicotinamide. It inhibits the viability of multiple B-cell acute lymphoblastic leukemia (B-ALL) cell lines with nanomolar potency and induces apoptosis in MV411 cells. It improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia, and targets leukemia stem cells.
Storage Temperature:
-20°C