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STF-118804

Supplier:
Catalogue number:
9552-25
Size:
25 mg
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STF-118804 is a potent and highly specific inhibitor of Nampt (nicotinamide phosphoribosyl transferase) (IC₅₀s = 3-6 nM) that prevents NAD⁺ synthesis from nicotinamide. It inhibits the viability of multiple B-cell acute lymphoblastic leukemia (B-ALL) cell lines with nanomolar potency and induces apoptosis in MV411 cells. It improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia, and targets leukemia stem cells.

Product Type:

Small Molecule Compounds

CAS Number:

894187-61-2

Alternative Names:

4-(5-methyl-4-(tosylmethyl)oxazol-2-yl)-N-(pyridin-3-ylmethyl)benzamide

Storage Temp:

-20°C

Compound Purity:

≥98% by HPLC

Molecular Weight:

461.53

UNSPSC Code:

12352100

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