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TGF-b3 Polyclonal Antibody - 5344-100 - 100 µg - BioVision - antibodies

TGF-b3 Polyclonal Antibody
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Size: 100 µg
£314.00
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Catalogue number:
5344-100
Name:
TGF-b3 Polyclonal Antibody
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The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2, TGF-beta3) signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development.

Data sheet:

Click to view / download

Applications:

Western blot

Product Type:
Antibodies
Alternative Names:
TGF-b3, TGF b3,TGF-beta3, TGF beta-3, TGFbeta, TGFb3, transforming growth factor beta 3
Species Reactivity:
Human, Mouse, Rat
Storage Temp:
-20°C
Antibody Host:
Rabbit
Antibody Isotype:
rabbit IgG
Antibody Type:
Polyclonal
UNSPSC Code:
12352203
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