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DR3 (Death Receptor 3/Apo3) Polyclonal Antibody - 3057-100 - 100 µg - BioVision - antibodies

DR3 (Death Receptor 3/Apo3) Polyclonal Antibody
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Size: 100 µg
£314.00
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Catalogue number:
3057-100
Name:
DR3 (Death Receptor 3/Apo3) Polyclonal Antibody
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Availability:

Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily through interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis through TRADD, FADD, and caspase-8. DR3 is highly expressed in the tissues enriched in lymphocytes including peripheral blood leucocytes (PBL), thymus and spleen.

Data sheet:

Click to view / download

Applications:

Western blot

Product Type:
Antibodies
Alternative Names:
Apo 3, LARD, TNFRSF12, TRAMP, TNFRSF25, WSL1
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide corresponding to residues surrounding amino acids 400 of human DR3.
Storage Temp:
-20°C
Antibody Host:
Rabbit
Antibody Isotype:
rabbit IgG
Antibody Type:
Polyclonal
UNSPSC Code:
12352203
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