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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
935666-88-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
348.8
Alternative Names:
5-chloro-n2-[(1s)-1-(5-fluoro-2-pyrimidinyl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)-2,4-pyrimidinediamine
- Data sheet: View or download
- MSDS: View or download
Product Description:
A selective JAK2 inhibitor that blocks signaling (IC50 = 58 nM at 5 mM ATP) and proliferation of JAK2-expressing cell lines (GI50 = 60 nM); displays good pharmacokinetics in vivo, inhibits STAT3 and STAT5 activation in vivo, and suppresses tumorigenesis in mouse xenografts harboring constitutive STAT3 activity
Storage Temperature:
-20°C