β-Amyloid (1-42)

Aβ (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aβ (1-42) is the principal species associated with senile plaque amyloids, while Aβ (1-40) is more abundant in cerebrovascular amyloid deposit.