This is a dimethylated lysine at position 4 of the 1-21 amino acid histone H3 peptide. This form of histone methylation is characterised as being enriched around transcription start sites (TSS). It has been observed that a subgroup of genes linked to T cell functions showed high levels of H3K4me2 within their gene body. While enrichment for H3K4me2 within the gene body is a characteristic trait of expressed genes in yeast, in contrast, H3K4me2 has been shown to be predominantly enriched around the TSS in mammals.
Proteins & Peptides
Peak Area by HPLC ≥95%
1, Tian Y. et al. PLOS One. 6(11):e27770 (2011) 2, Pekowska A. et al. Genome Res. 20, 1493-1502 (2010).