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Protease-Activated Receptor-3, PAR-3 Agonist, amide - ANA62938 - 1 mg - AnaSpec - proteins & peptides

Protease-Activated Receptor-3, PAR-3 Agonist, amide
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Size: 1 mg
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Protease-Activated Receptor-3, PAR-3 Agonist, amide

This peptide is one of the four PAR sub-types, and is acted upon by thrombin; not trypsin. It is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. PARs have been studied for their roles in itch and, their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR4. Co-expression of PAR3 and PAR4 enhances thrombin action suggesting that PAR3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR4.

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Proteins & Peptides
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Peak Area by HPLC ≥95%
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1, Tsujii, K. et al. J Pharmacol Sci. 108:385-388 (2008). 2, Leger, AJ. et al. Circ, 114:1070-1077 (2006).
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