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Amyloid-Forming Peptide GNNQQNY

Supplier:
Catalogue number:
ANA62762
Size:
1 mg
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This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.

Product Type:

Proteins & Peptides

Storage Temp:

-20°C

Compound Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

836.8

Reference:

Strodel, B. et al. J. Am. Chem. Soc. 129, 16005 (2007); Zhang, Z. et al. Biophys. J. 93, 1484 (2007); Zheng, J. et al. Biophys. J. 91, 824 (2006).

UNSPSC Code:

12352202