This peptide is amino acids 25 to 35 fragment of the β-amyloid biotinylated at C-terminus. This peptide possesses many of the characteristics of the full-length β-amyloid peptide, including an amphiphilic nature and an ability to aggregate, and can serve as a model system to study the conformational changes involved in Alzheimer's disease. Aggregates of β-amyloid (25–35) have been shown to possess the neurotrophic and neurotoxic properties of their full-length counterparts and there is evidence that the monomeric form of the peptide may itself be cytotoxic.
Proteins & Peptides
Peak Area by HPLC ≥95%
Wei, G. and J. Shea Biophys. J. 91, 1638 (2006).