This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic β cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunisation with this peptide in mice led to autoantibodies and insulitis.
- Data sheet/protocol: View or download
- MSDS: View or download
Product Type:
Proteins & Peptides
Storage Temp:
-20°C
Compound Purity:
Peak Area by HPLC ≥95%
Molecular Weight:
1645.9
Reference:
Devendra, D. et al. Diabetes 54, 2549 (2005). Starwalt, S. et al. Protein Eng. 16, 147 (2003); Lee, L. et al. PNAS 102, 15995 (2005).
UNSPSC Code:
12352202
Proteins & Peptides from AnaSpec: