Insulin B (9-23) - ANA61532 - 1 mg - AnaSpec - proteins & peptides
Insulin B (9-23)
Catalogue number:
ANA61532
Name:
Insulin B (9-23)
Supplier:
Availability:
This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic β cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.
Data sheet:
Product Type:
Proteins & Peptides
Alternative Names:
SHLVEALYLVCGERG
Storage Temp:
-20°C
Compound Purity:
Peak Area by HPLC ≥95%
Molecular Weight:
1645.9
Reference:
Devendra, D. et al. Diabetes 54, 2549 (2005). Starwalt, S. et al. Protein Eng. 16, 147 (2003); Lee, L. et al. PNAS 102, 15995 (2005).
UNSPSC Code:
12352202
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