£223.00
Estimated delivery Thu 25 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
Purity:
Peak Area by HPLC ≥95%
Molecular Weight:
1646
Product Description:
This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic β cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.
Storage Temperature:
-20°C