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Insulin B (9-23)

Supplier:
Catalogue number:
ANA61532
Size:
1 mg
Product is available in:
  • UK
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This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic β cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunisation with this peptide in mice led to autoantibodies and insulitis.

Product Type:

Proteins & Peptides

Storage Temp:

-20°C

Compound Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

1645.9

Reference:

Devendra, D. et al. Diabetes 54, 2549 (2005). Starwalt, S. et al. Protein Eng. 16, 147 (2003); Lee, L. et al. PNAS 102, 15995 (2005).

UNSPSC Code:

12352202