Cys(Npys)-(D-Arg)9

This is a peptide comprising of 9 D-Arginine residues and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group protects cysteine. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation and cell permable studies. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. In a bioconjugation study, D-Arg-C(Nyps) was shown to mediate delivery of TALEN proteins into mammalian cells.

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