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Cys(Npys)-(Arg)9

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Size:
1 mg _$$_
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£449.00 Estimated delivery Thu 28 Mar
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CAS Number:

1417221-06-7

Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

1680

Product Description:

This is a peptide comprising of 9 Arginine residues and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group protects cysteine. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation and cell permable studies. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. Coupling of sulfhydrils has been studied as an effective means to deliver/release therapeutics such as siRNA in the reducing environment within the cell. For example, in a study leukemic-specific SiRNA was delivered by the formation of immunocomplexes that consisted of targeted antibody conjugated to oligo-9-Arg peptides.

Storage Temperature:

-20°C

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