This peptide increases membrane microviscosity, intracellular Ca2+ concentration and cell migration in circulating leucocytes, and oxygen production in monocytes and neutrophils. It also induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell lines. PrP (106–126) stimulates leucocyte migration in a dose-dependent manner.
Proteins & Peptides
Peak Area by HPLC ≥95%
Ref: Diomede, L. et al. Biochem. J. 320, 563 (1996); Florio, T. et al. J. Neurosci. Res. 54, 341 (1998).