β-Amyloid (1-42), sodium salt

Aβ (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aβ (1-42) is the principal species associated with senile plaque amyloids, while Aβ (1-40) is more abundant in cerebrovascular amyloid deposit. This peptide prepared by neutralizing the TFA salt form of Aβ (1-42) with a diluted sodium hydroxide solution has superior solubility and fibrillogenesis properties, and the fibrils are equally neurotoxic.