This peptide corresponds to human keratin K18 amino acids 26-38, with an additional C-terminal cysteine. The sequence is identical to mouse K18 except that human K18 Val28 is replaced by alanine in the mouse sequence. Members of the 14-3-3 protein family bind the human intermediate filament protein keratin 18 (K18) in-vivo, in a cell-cycle- and phosphorylation-dependent manner. K18 Ser33 phosphorylation is essential for the association of K18 with 14-3-3 proteins and plays a role in keratin organization and distribution.
Product Type:
Proteins & Peptides
Storage Temp:
-20°C
Compound Purity:
Peak Area by HPLC ≥95%
Molecular Weight:
1418.5
Reference:
Ref: Ku, NO. et al. EMBO J. 17, 1892 (1998).
UNSPSC Code:
12352200
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