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TIM-4, Mouse, mAb Kat5-18, FITC - HM1111F - 100 µg - Hycult Biotech - antibodies

TIM-4, Mouse, mAb Kat5-18, FITC
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Size: 100 µg
£250.00
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Catalogue number:
HM1111F
Name:
TIM-4, Mouse, mAb Kat5-18, FITC
Supplier:
Availability:

The monoclonal antibody Kat5-18 recognizes T-cell immunoglobulin and mucin domain containing molecule (TIMD-4, also called TIM-4). TIMD-4 is a type I transmembrane protein belonging to the immunoglobulin superfamily, containing one Ig-like V-type (immunoglobulin-like) domain. TIMD-4 is expressed in Mac1+ cells in spleen, lymph nodes and fetal liver. TIMD-4 binds apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. TIMD-4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD-4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD-4 and TIMD-1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and are also involved in intracellular signaling in which exosomes are involved.</br> The monoclonal antibody Kat5-18 blocks the engulfment of apoptotic cells by thymic macrophages.

Applications:

FC , FS , IA , IF

Product Type:
Antibodies
Alternative Names:
TIMD4, TIM-4, T-cell immunoglobulin and mucin domain containing molecule
Immunogen:
Mouse peritoneal cells
Storage Temp:
2 - 8°C
Antibody Host:
Armenian hamster
Antibody Isotype:
IgG
Antibody Type:
Monoclonal antibody
Clone Number:
Kat5-18
UNSPSC Code:
12352203
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