www.bioscience.co.uk
Sales & Support: +44 (0)1223 316 855

*

Beta-Amyloid (1-28), Human

Supplier:
Catalogue number:
ANA24231
Size:
0.5 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£153.00 Shipping is calculated in checkout

The three-dimensional solution structure of Aβ (1-28) reveals the folding of the peptide to form a predominantly a-helical structure with a bend centered at residue 12 and the side chains of histidine-13 and lysine-16 in close proximity, residing on the same face of the helix. Their proximity may constitute a binding motif with the heparan sulfate proteoglycans. Aβ (1-28) is highly hydrophilic and shares sequences with bA4, the major component of Aβ. Its assembly is fibrillar, i.e., elongated in a single direction. Reports show that synthetic peptides Aβ (1-40) and Aβ (1-28) have significant effects on normal human plasma cholesterol esterification rate. Both peptides (at concentration of 1 ng/mL) inhibit plasma cholesterol esterification rate by 40-50% compared to the control value.

Product Type:

Proteins & Peptides

Storage Temp:

-20°C

Compound Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

3262.5

Reference:

Kirshenbaum K. and V. Daggett, Biochem. 34, 7640 (1995); Talafous, J. et al. Biochem. 33, 7788 (1994).

UNSPSC Code:

12352202