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β-Amyloid (12-28)

Catalogue number:
Supplier:
Size:
1 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£266.00 Estimated delivery Thu 4 Apr
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CAS Number:

107015-83-8

Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

1955.3

Product Description:

Aβ (12-28) represents a binding site for apolipoprotein E (apoE). ApoE is a genetically inherited risk factor for Alzheimer’s disease that promotes aggregation of toxic Aβ. This sequence encompasses a hydrophobic domain (residues 14–21) and a β-turn (residues 22–28) which place two hydrophobic domains of Aβ 14 to 21 and 29 to 40/42 opposite each other, allowing for the assembly of Aβ peptides into fibrils. The secondary structure of Aβ (12- 28), a neutral peptide, is dominated by a-helix and random coil. The interaction of apoE with residues 12 to 28 of Aβ is not just a non-specific hydrophobic interaction but plays a pivotal role in the mechanism of Aβ pathology in Alzheimer’s disease (AD). Aβ (11-28) and five other fragments enhanced aggregation of full length Aβ (1-40). All of the peptides that enhance aggregation contained either residues 17 to 20 or 30 to 35, indicating the importance of these regions for promoting aggregation of full-length Aβ.

Storage Temperature:

-20°C

Details Cat number & supplier Size Price
β-Amyloid (12-28) ANA24229 · AnaSpec
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β-Amyloid (25-35) ANA24227 · AnaSpec
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β-Amyloid (1-38) ANA24233 · AnaSpec
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β-Amyloid (1-16) ANA24226 · AnaSpec
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β-Amyloid (1-38) ANA24234 · AnaSpec
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β-Amyloid (1-16) ANA24225 · AnaSpec
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β-Amyloid (1-40) ANA24235 · AnaSpec
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β-Amyloid (1-42) ANA24224 · AnaSpec
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