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VIP, human, porcine, rat

Supplier:
Catalogue number:
ANA22873
Size:
1 mg
Product is available in:
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28-amino acid neuropeptide VIP (Vasoactive Intestinal Peptide) is a neurotransmitter and a neuromodulator. VIP is broadly distributed in the peripheral and central nervous systems. It has an amino acid sequence identity of 68% with pituitary adenylate cyclase-activating polypeptide (PACAP). VIP and PACAP inhibit TNF-a, IL-1β, IL-6, and NO production by lipopolysaccharide (LPS)-activated microglia. Both regulate the production of proinflammatory factors at a transcriptional level by inhibiting p65 nuclear translocation and nuclear factor-kB-DNA binding. As well, VIP relaxes the smooth muscle of the respiratory, gastrointestinal and reproductive tracts, stimulates exocrine and endocrine secretion, increases the survival time of neurons, and promotes the proliferation of untransformed andCancer cells.

Product Type:

Proteins & Peptides

Storage Temp:

-20°C

Compound Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

3325.9

Reference:

Paul, S. et al. J Biol Chem 276, 28314 (2001)Paul, S. et al. J Biol Chem 266,16128 (1991)Delgado, M. et al. J. Leukocyte Biol 73, 155 (2003)Yamamoto, K. et al. Diabetes 52, 1155 (2003)Ganea, D. Cell Mol Biol (Noisy-le-grand) 49, 127 (2003)Poso, D. and M. Delgado, FASEB J 18, 1325 (2004)Romano, D. et al. J Biol Chem 278, 51386 (2003).

UNSPSC Code:

12352202