ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers aSignal Transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.
Proteins & Peptides
Peak Area by HPLC ≥95%
Ref: Yanagisawa, M. et al. Nature. 332, 411 (1988).