Like human Gastrin-1 “Little Gastrin,” rat Gastrin-1 “Little Gastrin” contains 17 amino acids, but differs from human Gastrin by 3 amino acids at the C-terminus. Secretion of Gastrin is induced by food intake and causes the release of gastric acid. Synthesized by the G cells in the gastric mucosa, it is one of the major bioactive forms of Gastrin (the other bioactive form is Gastrin-34). Both Gastrin-17 and Gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of Gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor.
- Data sheet/protocol: View or download
- MSDS: View or download
Proteins & Peptides
-20°C
Peak Area by HPLC ≥95%
2126.3
Reeve, JR. et al. Peptides 2, 453 (1981)Schaffer, MH. et al. Peptides 3, 693 (1982), doi: 10.1016/0196-9781(82)90172-3Niederle, B. Wien Klin Wochenschr 119, 561 (2007), doi: 10.1007/s00508-007-0897-x.O’Connor A. et. al. Digestive Dis 32, 186 (2014), doi: 10.1159/000357848Dockray, G. et.al. Pflügers Archiv 449,344 (2005)Bundgaard, JR. et al. J Biol Chem 272, 21700 (1997), doi: 10.1074/jbc.272.35.21700Yakabi, K. et al. World J Gastroenterol 14, 6334 (2008), doi: 10.3748/wjg.14.6334
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