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ANP(1-28), rat

Catalogue number:
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Size:
0.5 mg _$$_
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£252.00 Estimated delivery Thu 28 Mar
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CAS Number:

88898-17-3

Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

3062.6

Product Description:

A-type (Atrial) natriuretic peptide (ANP), also called Cardiodilatine (CDD), is a peptide hormone composed of 28 amino acids. It is processed from a 151aa prepro-ANP by signal peptide removal, followed by specific protease cleavage by corin of the pro-ANP. The 28a C-terminal peptide hormone contains a 17aa ring formed by a disulfide bridge between Cys7 and Cys23. and a tail. It is produced in cardiac myocytes, where it exerts vasodilating effects, hence playing an important role in the regulation of blood pressure and natriuresis/diuresis. Residues Phe8, Arg14 and the C-terminal sequence of ANP are known to bind to human NPR-A (Natriuretic peptide receptor type A). ANP is closely related to BNP (brain natriuretic peptide) and CNP (C-type natriuretic peptide), which share a similar ring structure.
Rat ANP differs from the human hormone by only one residue at position 12.

Storage Temperature:

-20°C

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