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Securinine

Supplier:
Catalogue number:
s1609-100 mg
Size:
100 mg
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
£389.00 Estimated delivery Tue 28 Sep
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Alkaloid found in Securinega; potential GABA-A antagonist.

Product Type:

Biochemicals

CAS Number:

5610-40-2

Storage Temp:

-20°C

Compound Purity:

≥98%

Molecular Weight:

217.26

Reference:

Han S, Zhang G, Li M, et al. L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 and influences the expression of genes involved in the PI3K/AKT/mTOR signaling pathway. Oncol Rep. 2014 May;31(5):2245-51. PMID: 24676995. Li M, Han S, Zhang G, et al. Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells. Pharmazie. 2014 Mar;69(3):217-23. PMID: 24716413. Shipman M, Lubick K, Fouchard D, et al. Proteomic and systems biology analysis of monocytes exposed to securinine, a GABA(A) receptor antagonist and immune adjuvant. PLoS One. 2012;7(9):e41278. PMID: 23028424. Singh AK, Pandey MB, Singh S, et al. Antifungal Activity of Securinine against Some Plant Pathogenic Fungi. Mycobiology. 2008 Jun;36(2):99-101. PMID: 23990741. Lin X, Jun-Tian Z. Neuroprotection by D-securinine against neurotoxicity induced by beta-amyloid (25-35). Neurol Res. 2004 Oct;26(7):792-6. PMID: 15494124. Rana S, Gupta K, Gomez J, et al. Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells. FASEB. 2010 Jun;24(6):2126-2134. PMID: 20133503.

Structure:

C13H15NO2

Formula:

C13H15NO2

UNSPSC Code:

12352200

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