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Metformin Hydrochloride

Supplier:
Catalogue number:
m2076-5 g
Size:
5 g
Product is available in:
  • UK
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£37.00 Estimated delivery Tue 28 Sep
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AMPK activator.

Product Type:

Biochemicals

CAS Number:

1115-70-4

Alternative Names:

Dimethylbiguanide hydrochloride, Imidodicaronimidic diamide, N,N-dimethyl-, monohydrochloride, N,N-Dimethylbiguanide hydrochloride

Storage Temp:

Ambient

Compound Purity:

≥98%

Molecular Weight:

165.62

Reference:

Fan C, Wang Y, Liu Z, et al. Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer. Int J Mol Med. 2015 May 21. [Epub ahead of print]. PMID: 25999130. Miyoshi H, Kato K, Iwama H, et al. Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo. Int J Oncol. 2013 Dec 30. [Epub ahead of print]. PMID: 24378856. Piwkowska A, Rogacka D, Jankowski M, et al. Metformin reduces NAD(P)H oxidase activity in mouse cultured podocytes through purinergic dependent mechanism by increasing extracellular ATP concentration. Acta Biochim Pol. 2013;60(4):607-12. PMID: 24432311. Akinyeke T, Matsumura S, Wang X, et al. Metformin targets c-MYC oncogene to prevent prostate cancer. Carcinogenesis. 2013 Dec;34(12):2823-32. PMID: 24130167. Zhang Y, Guan M, Zheng Z, et al. Effects of metformin on CD133+ colorectal cancer cells in diabetic patients. PLoS One. 2013 Nov 21;8(11):e81264. PMID: 24278407. Shin S, Hyun B, Lee A, et al. Metformin Suppresses MHC-Restricted Antigen Presentation by Inhibiting Co-Stimulatory Factors and MHC Molecules in APCs. Biomol Ther (Seoul). 2013 Jan;21(1):35-41. PMID: 24009856. Chu CA, Wiernsperger N, Muscato N, et al. The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis. Metabolism. 2000 Dec;49(12):1619-26. PMID: 11145127. Lin HZ, Yang SQ, Chuckaree C, et al. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med. 2000 Sep;6(9):998-1003. PMID: 10973319. Minassian C, Tarpin S, Mithieux G. Role of glucose-6 phosphatase, glucokinase, and glucose-6 phosphate in liver insulin resistance and its correction by metformin. Biochem Pharmacol. 1998 Apr 15;55(8):1213-9. PMID: 9719475. Stumvoll M, Nurjhan N, Perriello G, et al. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med. 1995 Aug 31;333(9):550-4. PMID: 7623903. Nakamichi N, Shima H, Asano S, et al. Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. J Pharm Sci. 2013 Sep;102(9):3407-3417. PMID: 23666872.

Structure:

C4H11N5 HCl

Formula:

C4H11N5 HCl

UNSPSC Code:

12352200

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