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Selumetinib

Supplier:
Catalogue number:
s1846-10 mg
Size:
10 mg
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
£84.00 Estimated delivery Tue 28 Sep
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MEK1/2 inhibitor.

Product Type:

Biochemicals

CAS Number:

606143-52-6

Alternative Names:

AZD6244, ARRY 142886

Storage Temp:

Ambient

Compound Purity:

≥98%

Molecular Weight:

457.68

Reference:

Paolo M, Assunta S, Antonio R, et al. Selumetinib in Advanced Non Small Cell Lung Cancer (NSCLC) Harbouring KRAS Mutation: Endless Clinical Challenge to KRAS-mutant NSCLC. Rev Recent Clin Trials. 2013 Jun;8(2):93-100. PMID: 24063423. Muchir A, Kim YJ, Reilly SA, et al. Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation. Skelet Muscle. 2013 Jul 1;3(1):17. PMID: 23815988. Shindo T, Kim TK, Benjamin CL, et al. MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner. Blood. 2013 Jun 6;121(23):4617-26. PMID: 23575444. Sabnis GJ, Kazi A, Golubeva O, et al. Effect of selumetinib on the growth of anastrozole-resistant tumors. Breast Cancer Res Treat. 2013 Apr;138(3):699-708. PMID: 23508762. Huynh H, Soo KC, Chow PK, et al. Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. Mol Cancer Ther. 2007 Jan;6(1):138-46. PMID: 17237274.

Structure:

C17H15BrClFN4O3

Formula:

C17H15BrClFN4O3

UNSPSC Code:

12352200

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