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BRM bromodomain TR-FRET Assay Kit

Catalogue number:
CAY600730-9600 wells
Supplier:
Size:
9600 wells _$$_
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Alternative Names:

smarca2

Product Description:

The SWI/SNF family of ATP-dependent chromatin remodeling enzymes catalyzes structural changes that allow proteins to access the nucleosomal DNA, alter the position of the nucleosomes on the DNA, or eject the histone octamer from the template. Mammalian SWI/SNF remodelers contain either BRM (SMARCA2) or BRG1 (SMARCA4) as their catalytic subunit. These subunits also contain a C-terminal bromodomain that binds to acetylated residues on histone tails. Small molecule inhibitors of BRM interactions with peptide binding partners hold promise as useful therapeutics for human disease. Cayman’s BRM bromodomain TR-FRET Assay Kit is a homogeneous, TR-FRET assay method amenable to rapid characterization of inhibitors of bromodomain/acetylated peptide interaction in a high throughput format. This screening assay is robust, displaying a Z' >0.6.

Storage Temperature:

-80°C

CAY600730-9600 wells: BRM bromodomain TR
CAY600730-9600 wells: BRM bromodomain TR-FRET Assay Kit
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