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Satraplatin

Supplier:
Catalogue number:
s0278-50 mg
Size:
50 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£1498.00 Estimated delivery Tue 28 Sep
Shipping is calculated in checkout

Pt-based DNA cross-linker.

Product Type:

Biochemicals

CAS Number:

129580-63-8

Alternative Names:

Poplat

Storage Temp:

-20°C

Compound Purity:

≥98%

Molecular Weight:

498.26

Reference:

Figg WD, Chau CH, Madan RA, et al. Phase II study of satraplatin and prednisone in patients with metastatic castration-resistant prostate cancer: a pharmacogenetic assessment of outcome and toxicity. Clin Genitourin Cancer. 2013 Sep;11(3):229-37. PMID: 23684781. Kalimutho M, Minutolo A, Grelli S, et al. Satraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistance. Cancer Chemother Pharmacol. 2011 Jun;67(6):1299-312. PMID: 20734047. Yamano Y, Shiiba M, Negoro K, et al. Antitumor activity of satraplatin in cisplatin-resistant oral squamous cell carcinoma cells. Head Neck. 2011 Mar;33(3):309-17. PMID: 20848452. Fokkema E, Groen HJ, Helder MN, et al. JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation, glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin. Biochem Pharmacol. 2002 Jun 1;63(11):1989-96. PMID: 12093475.

Structure:

C10H22Cl2N2O4Pt

Formula:

C10H22Cl2N2O4Pt

UNSPSC Code:

12352200

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