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Brefeldin A

Supplier:
Catalogue number:
b6816-5 mg
Size:
5 mg
Product is available in:
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£80.00 Estimated delivery Tue 28 Sep
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Lactone found in fungi such as Eupenicillium; guanine nucleotide exchange factor inhibitor.

Product Type:

Biochemicals

CAS Number:

20350-15-6

Alternative Names:

Ascotoxin, Cyanein, Decumbin

Storage Temp:

-20°C

Compound Purity:

≥97%

Molecular Weight:

280.36

Reference:

Zhou C, Li C, Li D, et al. BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways. Neuroscience. 2013 Dec 19;254:361-8. PMID: 24090963. Rouhana J, Padilla A, Estaran S, et al. Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A. J Biol Chem. 2013 Feb 15;288(7):4659-72. PMID: 23255605. Chapman JR, Tazaki H, Mallouh C, et al. Brefeldin A-induced apoptosis in prostatic cancer DU-145 cells: a possible p53-independent death pathway. BJU Int. 1999 Apr;83(6):703-8. PMID: 10233583. Cuconati A, Molla A, Wimmer E. Brefeldin A inhibits cell-free, de novo synthesis of poliovirus. J Virol. 1998 Aug;72(8):6456-64. PMID: 9658088.

Structure:

C16H24O4

Formula:

C16H24O4

UNSPSC Code:

12352200

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