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18β-Glycyrrhetinic Acid

Supplier:
Catalogue number:
g4597-25 g
Size:
25 g
Product is available in:
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£234.00 Estimated delivery Tue 5 Oct
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Triterpene glycoside found in Glycyrrhiza; 15-HPGDH inhibitor, hERG and KCNA3/Kv1.3 K+ channel blocker.

Product Type:

Biochemicals

CAS Number:

471-53-4

Alternative Names:

Enoxolone, Uralenic acid, Arthrodont, Biosone

Storage Temp:

Ambient

Compound Purity:

≥98%

Molecular Weight:

470.68

Reference:

Jayasooriya RG, Dilshara MG, Park SR, et al. 18β-Glycyrrhetinic acid suppresses TNF-α induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-κB pathway. Toxicol In Vitro. 2014 Aug;28(5):751-8. PMID: 24613819. Park M, Lee JH, Choi JK, et al. 18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity. Mol Nutr Food Res. 2014 Jul;58(7):1436-46. PMID: 24687644. Song J, Ko HS, Sohn EJ, et al. Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1188-91. PMID: 24461294. Wu D, Jiang L, Wu H, et al. Inhibitory effects of glycyrrhetinic Acid on the delayed rectifier potassium current in Guinea pig ventricular myocytes and HERG channel. Evid Based Complement Alternat Med. 2013;2013:481830. PMID: 24069049. Fu XX, Du LL, Zhao N, et al. 18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells. J Ethnopharmacol. 2013 Jul 9;148(2):647-54. PMID: 23707333.

Structure:

C30H46O4

Formula:

C30H46O4

UNSPSC Code:

12352200

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