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Rat Anti-Mouse Ly-6A/E-AF488

Supplier:
Catalogue number:
1755-30
Size:
0.1 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£219.00 Estimated delivery Fri 28 Jan
Shipping is calculated in checkout

Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NsB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.

Product Type:

Antibodies

Alternative Names:

Sca-1

Species Reactivity:

Mouse

Immunogen:

IL-2 dependent mouse (C57BL/6) cytotoxic T cell line CTL-L

Storage Temp:

2 - 8°C

Antibody Host:

Rat

Antibody Isotype:

IgG2a

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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