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Rat Anti-Mouse CD62L-AF647

Supplier:
Catalogue number:
1705-31
Size:
0.1 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£219.00 Estimated delivery Fri 28 Jan
Shipping is calculated in checkout

CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and epidermal growth factor-like domains. It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes. In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.

BALB/c mouse splenocytes were stained wi
Product Type:

Antibodies

Alternative Names:

L-selectin, LECAM-1, LAM-1, Ly-22, Sell, Lnhr, Lyam-1

Species Reactivity:

Mouse

Immunogen:

C3H/eb cloned mouse B cell lymphoma 38C-13

Storage Temp:

2 - 8°C

Antibody Host:

Rat

Antibody Isotype:

IgG2a

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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