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Mouse Anti-Mouse CD45.2-AF647

Catalogue number:
Supplier:
Size:
0.1 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£243.00 Estimated delivery Fri 19 Aug
Shipping is calculated in checkout
Applications:

FC, IHC-FS

Antibody Host:

Mouse

Species Reactivity:

Mouse

Antibody Isotype:

IgG2a

Antibody Type:

Monoclonal

Immunogen:

B10.S mouse thymocytes and splenocytes

Alternative Names:

Ly-5.2, LCA, SJL, T200

C57BL/6 mouse splenocytes were stained w

The CD45 antigen is an essential regulator of leukocyte activation and development and is now known to be a protein tyrosine phosphatase, e.g., CD45 is able to dephosporylate the Src family of protein kinases. This activity is known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling, and Fc receptor stimulation. The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants (CD45R; see companion products 1660, 1665, 1675, 1685 and 1820) and as allelic forms CD45.1 (Ly-5.1) and CD45.2 (Ly-5.2). The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. The monoclonal antibody 104 recognises CD45 (leukocyte common antigen) on all leukocytes of mouse strains expressing the CD45.2 allotype (e.g., A, AKR, BALB/c, CBA/Ca, CBA/J, C3H/He, C57BL, C57BR, C57L, C58, DBA/1, DBA/2, NsB, SWR, 129).

Storage Temperature:

2 - 8°C

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