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Rat Anti-Mouse CD54-AF647

Supplier:
Catalogue number:
1701-31
Size:
0.1 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£232.00 Estimated delivery Fri 28 Jan
Shipping is calculated in checkout

CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes, and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN γ, IL-1, TNF-α, lipopolysaccharide, and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.

C57BL/6 mouse splenocytes were stained w
Product Type:

Antibodies

Alternative Names:

ICAM-1, Ly-47

Species Reactivity:

Mouse, Porcine

Immunogen:

Mouse NS-1 cells

Storage Temp:

2 - 8°C

Antibody Host:

Rat

Antibody Isotype:

IgG2b

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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