www.bioscience.co.uk
Sales & Support: +44 (0)1223 316 855

*

TLR4, Human, mAb HTA125, PE

Catalogue number:
HM2068PE-100
Supplier:
Size:
100 tests _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£382.00 Shipping is calculated in checkout
Applications:

Flow cytometry, Functional studies, Immuno assays, Immuno fluorescence, Immuno precipitation, Western blot

Immunogen:

BALB/c mice were immunized with the Ba/F3 line expressing TLR4.

Product Description:

Toll-like receptors (TLRs) are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs constitute of a family of pattern recognition receptors (PRRs) that mediate cellular responses to a large variety of pathogens (viruses, bacteria, and parasites) by specific recognition of so-called ‘pathogen-associated molecular patterns’. Activation of TLRs, a family of at least 11 different members that function either as homo- or heterodimers, leads to activation of NFκB-dependent and IFN-regulatory factor-dependent signaling pathways. TLRs have a central role in innate immunity and are also required for the development of an adaptive immune response. TLRs are expressed by various cells of the immune system, such as macrophages and dendritic cells. TLRs are class I receptors, with a single α-helix that spans the cell membrane. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens, such as lipopolysaccharide (LPS) from the outer membrane of Gram negative bacteria, peptidoglycan fragments from bacterial cell walls and single-stranded and double-stranded RNA from viruses. Toll-like receptor 4 (TLR4; CD284) has been identified, next to MD-2 and CD14, as a receptor that is central to the innate immune response to LPS of Gram-negative bacteria. TLR4 is unique among TLRs in its ability to activate two distinct signaling pathways; one pathway is activated by the adaptors TIRAP (Toll/interleukin-1- receptor (TIR)-domain-containing adaptor protein) and MyD88, which leads to the induction of pro‑inflammatory cytokines. The second pathway is activated by the adaptors TRIF (TIR-domaincontaining adaptor protein inducing interferon‑β) and TRAM (TRIFrelated adaptor molecule), which leads to the induction of type I interferons. The monoclonal antibody HTA125 is a TLR4 function-blocking antibody. HTA125 recognizes preferentially human TLR4 that is associated with MD-2.

HM2068PE-100 TLR4, Human, mAb HTA125, PE
HM2068PE-100 TLR4, Human, mAb HTA125, PE
Details Cat number & supplier Size Price
TLR4, Human, mAb HTA125, PE HM2068PE-25 · Hycult Biotech
HM2068PE-25
Hycult Biotech
25 tests £194.00
25 tests
view
IFN-alpha, Mouse, mAb F18 HM1001-20UG · Hycult Biotech
HM1001-20UG
Hycult Biotech
20 µg £132.00
20 µg
view
IFN-gamma, Mouse, mAb F3 HM1002-20UG · Hycult Biotech
HM1002-20UG
Hycult Biotech
20 µg £132.00
20 µg
view
IFN-gamma, Mouse, mAb F1 HM1003-20UG · Hycult Biotech
HM1003-20UG
Hycult Biotech
20 µg £132.00
20 µg
view
IL-6, Mouse, mAb MP5-20F3 HM1004-20UG · Hycult Biotech
HM1004-20UG
Hycult Biotech
20 µg £132.00
20 µg
view
IL-6, Mouse, mAb MP5-32C11 HM1005-20UG · Hycult Biotech
HM1005-20UG
Hycult Biotech
20 µg £132.00
20 µg
view
TNF-RI, Mouse, mAb HM104 HM1009-20UG · Hycult Biotech
HM1009-20UG
Hycult Biotech
20 µg £132.00
20 µg
view
TNF-RI, Mouse, mAb HM104, FITC HM1009F-20UG · Hycult Biotech
HM1009F-20UG
Hycult Biotech
20 µg £132.00
20 µg
view
TNF-RII, Mouse, mAb HM102 HM1011-20UG · Hycult Biotech
HM1011-20UG
Hycult Biotech
20 µg £132.00
20 µg
view
TNF-RII, Mouse, mAb HM102, FITC HM1011F-20UG · Hycult Biotech
HM1011F-20UG
Hycult Biotech
20 µg £132.00
20 µg
view