BTT3033

An integrin α2β1 inhibitor α2β1 (EC50 = 130 nM in CHO cells expressing the human receptor); 8-fold selective for integrin α2β1 over integrin α1β1, as well as laminin 332, 40 kDa fibronectin, 120 kDa fibronectin, and vitronectin at 130 nM; inhibits the adhesion of platelets in isolated mouse whole blood to collagen I-coated capillaries at a constant shear rate (EC50 = 6 µM); decreases lavage fluid leukocyte infiltration in a mouse model of platelet-activating factor-induced air pouch inflammation at 10 mg/kg, p.o.; decreases ear thickness in a mouse model of ovalbumin- and alum-induced mouse model of skin hypersensitivity at 10 mg/kg