www.bioscience.co.uk
Sales & Support: +44 (0)1223 316 855

*

Complement factor B/Bb, Human, mAb M13/12

Catalogue number:
Supplier:
Size:
100 µg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
N/A
Shipping is calculated in checkout
This product is no longer available to order.
Applications:

IA , IP , W

Antibody Host:

Mouse

Antibody Isotype:

IgG1

Antibody Type:

Monoclonal antibody

Product Description:

The monoclonal antibody M13/12 recognizes human complement factor B/Bb. Factor B is an acute-phase protein. Levels of factor B increase during inflammation. Complement factor B is a single- chain molecule of 764 amino acids (MW of 90 kD), including a leader peptide of 25 amino acids. Complement factor B provides the catalytic subunit of the C3/C5 convertases of the alternative complement pathway. Assembly of the C3 convertase (C3bBb) requires binding of complement factor B to C3b (C3.H2O) and factor D-mediated cleavage of bound complement factor B resulting in the release of Ba (MW 33 kD). The C3 convertase is stabilized by the binding of properdin. This provides a positive amplification loop for the classical and alternative complement pathways. Bb (MW 60 kD) is the serine protease element of this convertase. After cleavage of C3, the C5 convertase ((C3b)2Bb) is formed. The Bb fragment may be regarded as a better indicator of the alternative pathway of complement activation than Ba as impaired renal filtration does directly influence Ba levels. Whereas Bb is elevated 2.2-fold in chronic renal failure (CRF) patients, plasma concentrations of Ba are 8.4-fold higher in CRF and 16-fold higher in end-stage renal disease (ESRD) patients compared to normals. In addition to complement activation, factor B fragments participate in other immunological functions.

Storage Temperature:

2 - 8°C

HM2256 Complement factor B/Bb, Human, mA
HM2256 Complement factor B/Bb, Human, mAb M13/12
Details Cat number & supplier Size Price
Complement factor H, Human, ELISA kit HK342-02 · Hycult Biotech
HK342-02
Hycult Biotech
2 x 96 determinations £1345.00
2 x 96 determinations
view
TCC, Rat, ELISA kit HK106-02 · Hycult Biotech
HK106-02
Hycult Biotech
2 x 96 determinations £1345.00
2 x 96 determinations
view
Alternative Complement Pathway, Rat, Assay HIT412 · Hycult Biotech
HIT412
Hycult Biotech
96 determinations £885.00
96 determinations
view
Complement Pathway, Rat, Assay HIT413 · Hycult Biotech
HIT413
Hycult Biotech
3 x 96 determinations £1766.00
3 x 96 determinations
view
sCD59, Human, ELISA kit HK374-02 · Hycult Biotech
HK374-02
Hycult Biotech
2 x 96 determinations £1345.00
2 x 96 determinations
view
Cobra Venom Factor, Recombinant HC4073-50UG · Hycult Biotech
HC4073-50UG
Hycult Biotech
50 µg £545.00
50 µg
view
C3a/C3a des Arg, Human, mAb 2991 HM2074-100UG · Hycult Biotech
HM2074-100UG
Hycult Biotech
100 µg £410.00
100 µg
view
TCC, Human, mAb aE11 HM2167-100UG · Hycult Biotech
HM2167-100UG
Hycult Biotech
100 µg £505.00
100 µg
view
C1s/C1-INH, Human, ELISA HK399-02 · Hycult Biotech
HK399-02
Hycult Biotech
2 x 96 determinations £1428.00
2 x 96 determinations
view