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Human CellExp™ PON1, Human Recombinant

Supplier:
Catalogue number:
P1556-50
Size:
50 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£632.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

PON1, also known as A esterase1, is a member of the paraoxonase family. It is an enzyme that hydrolyses the toxic metabolites of a variety of organophosphorus insecticides. It is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). This protein is activated by PPAR-gamma, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis. PON1 shows a variety of atheroprotective properties by metabolising inflammatory lipid peroxides. It has evolved to be a highly promiscuous enzyme capable of hydrolysing a wide variety of substrates such as lactones, cyclic carbonates, organophosphorus pesticides and nerve gases. Recombinant human PON1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Type:

Proteins and peptides

Alternative Names:

Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1, paraoxonase 1, ESA, MVCD5, PON

Storage Temp:

-20°C

Molecular Weight:

39.0--

UNSPSC Code:

12352202

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